PHILADELPHIA -- Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does ...

Our brains contain billions of neurons and trillions of connections, and scientists are only beginning to understand the intricate process required to build this level of complexity. This includes ...

Phase II trial of the oral mTOR inhibitor everolimus (RAD001) for patients with relapsed or refractory lymphoma Mantle Cell Lymphoma (MCL) represents only 5–10% of all non-Hodgkins lymphomas, making ...

Comparative effectiveness of treatment strategies for urothelial cancer of the bladder (UCB) with clinical lymph node involvement (cN+). Anti-tumor activity, safety and pharmacokinetics (PK) of AGS15E ...

Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional ...

Causeway Therapeutics, a clinical-stage biotechnology company developing novel medicines for tendon disease, today announced positive topline data from its Phase 2 clinical trial evaluating TenoMiR ® ...

Dr. Yogesh Dwivedi authored a book chapter “microRNA Function and Dysregulation in Depression and Suicide” in Suicide Phenomenology and Neurobiology, Edited by: Keri Cannon and Thomas Hudzik.

This year’s Nobel Prize in Medicine was awarded to Victor Ambros and Gary Ruvkun, as announced by the Nobel Assembly at the Karolinska Institute in Stockholm on October 7. Gary Ruvkun, professor of ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...