KATMAP: A new way to understand and predict gene splicing

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able ...
Frontiers

B cell subpopulations and their role in the pathogenesis of primary Sjögren’s syndrome: insights from single-cell RNA sequencing

Objective: This study aims to investigate the potential role of B cells in the pathogenesis of Primary Sjögren’s Syndrome (pSS) by analyzing cell types, differentially expressed genes, and associated ...
SciTech Daily

New Tool Reads DNA and RNA in a Single Cell, Unlocking Secrets of Disease

For centuries, scientists have recognized that certain illnesses can run in families, an idea that dates back to Hippocrates. Over time, researchers have become increasingly skilled at uncovering how ...
Frontiers

RNA sequencing enables neoantigen discovery and vaccine validation in breast and lung cancer

Introduction: Neoantigens have emerged as promising targets for personalized cancer immunotherapy due to their tumor-specific immunogenicity. However, current neoantigen prediction methods relying on ...
ahajournals.org

Abstract Wed043: Genetic Variants in RNA Binding Motif Protein 20 Cause Early-onset Heart Failure by Disrupting Post-Transcriptional Process

Introduction: RNA binding motif protein 20 (RBM20) cardiomyopathy is a severe form of dilated cardiomyopathy (DCM), leading to early-onset heart failure (HF). The condition has been linked to ...