When to worry about flatulence - what is a normal amount to pass wind... and when could it be a sign of cancer

Flatulence is an entirely normal process which occurs up to 20 times a day, often the sign of a healthy gut. But there are ...
C&EN

The Role of Protein Side Chains in Enzyme-Activating Conformational Changes: Lessons from Studies on Variant Enzymes

You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters ...
FierceBiotech

Denali's Hunter syndrome drug latest to be hit by FDA decision delay

Denali Therapeutics has become the latest on a growing list of biotechs to experience an FDA review delay in recent months. The agency in July accepted an application for Denali's enzyme replacement ...
Medical Xpress

Targeting enzymes to weaken cancer cells could supercharge prostate cancer treatment

An international study has uncovered a new vulnerability in prostate cancer cells that could help improve treatment for one of the most common cancers affecting men. The research, published in the ...
C&EN

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery

Hypha Discovery Limited, 154B Brook Drive, Milton Park, Abingdon OX14 4SD, U.K. Mode of Action Group, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, ...
PNAS

Distantly related bacteria share a rigid proteome allocation strategy with flexible enzyme kinetics

Contributed by Terence Hwa; received December 27, 2024; accepted March 21, 2025; reviewed by Vickery L. Arcus and Seppe Kuehn ...
Business Wire

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological ...
Phys.org

AI tool helps match enzymes to substrates

A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination for applications ...
Phys.org

Enhancing the industrial relevance of alcohol dehydrogenase enzymes by exploiting their 'hidden reactivity'

Amides and thioesters are ubiquitous compounds in chemistry, used for the production of medicines, natural products, and advanced materials. Traditionally, their synthesis is a messy business, ...