The AAV carrier substances have an advantageous safety profile and high gene transfer efficiency, meaning they are often used in gene therapies and in gene editing with CRISPR/Cas. But, AAVs have ...

One problem in gene therapy is that not all genes transfer equally well into the target cells. Researchers have now developed a flexible method to transfer large genes efficiently and without ...

No currently available treatment is able to generate new contractile tissue or significantly improve cardiac function after myocardial infarction (MI), a leading cause of morbidity and mortality ...

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore tissues and organs damaged ...

Pancreatic cancer has a significantly poor prognosis; therefore, the development of effective treatments is an unmet clinical need. The major drawback in this field was the lack of useful model ...

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore tissues and organs damaged ...

In the first human trial to investigate gene transfer as a treatment for impotence, also referred to as erectile dysfunction, the approach appeared to be safe and provided some evidence that it is ...

Theodore Friedmann, professor of pediatrics at the University of California, San Diego, is also director of the Program in Gene Therapy there. The overriding interest of his laboratory is gene therapy ...

Researchers in South Korea have proposed a novel cancer immunotherapy approach that could complement existing CAR-T (Chimeric Antigen Receptor T-cell) treatments. The work is published in the journal ...