Indian Defence Review on MSN

Scientists Say This Arctic Animal’s DNA Could Be the Secret to Human Longevity

Bowhead whales, Earth's longest-living mammals, produce a unique protein that repairs DNA damage. This discovery could help ...

Tying protein to fraying DNA solves mystery of illness for patients around the world

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining ...
Frontiers

Mutation profile and molecular heterogeneity in mismatch repair deficient endometrial carcinoma

1 Department of Pathology, State Key Laboratory of Complex Severe and Rare Disease, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and ...
UroToday

Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair.

Clinical trials show benefit of the combination of poly(ADP-ribose) polymerase inhibitors (PARPi) with androgen receptor (AR) pathway inhibitors (ARPi) in metastatic, castration-resistant prostate ...
Indian Defence Review

Naked Mole-Rat’s DNA Mutation Unlocks the Key to Aging Gracefully

The naked mole-rat is a remarkable creature, known for its extraordinary longevity. This small, hairless rodent is capable of living much longer than would be expected for an animal of its size. While ...
Frontiers

Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with limited treatment options and poor prognosis. Recent advances in cancer genomic analysis enable the ...
THE WEEK

Babies born using 3 people's DNA lack hereditary disease

Mitochondria are widely known as the "powerhouse of the cell" because of their ability to generate energy in the body and convert nutrients from food. With such an essential job, mutations in ...
ascopubs.org

AlphaMissense for Identifying Pathogenic Missense Mutations in DNA Damage Repair Genes in Cancer

Relationship Among DNA Damage Response Gene Alterations, Molecular Subtypes, and Survival Outcomes in Patients With Metastatic Bladder Cancer Treated on CALGB 90601 Sequencing data from 56,965 ...
News Medical

Scientists use base editing to repair mitochondrial DNA mutations

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...
ascopubs.org

Synthetic Lethal Co-Mutations in DNA Damage Response Pathways Predict Response to Immunotherapy in Pan-Cancer

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...
emjreviews.com

ESMO 2025: DNA Repair Mutations May Reduce Therapy Response

A NEW study presented at ESMO Breast 2025 explores the impact of inherited mutations in DNA repair genes on the effectiveness of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone ...