Powerful tool can map gene regulation at single-nucleotide resolution

Understanding how cells turn genes on and off is one of biology's most enduring mysteries. Now, a new technology developed by ...

Gene CEP76 sheds light on cause of rare ciliopathy disorders

A Northwestern Medicine-led study has identified mutations in the gene CEP76 as a new cause of ciliopathies, shedding light on a complex group of disorders that affect multiple body systems, according ...
eLife

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

This important study examines the potential role of ARHGAP36 transcriptional regulation by FOXC1 in controlling sonic hedgehog signaling in human neuroblastoma. While there are many solid findings ...
American Association for the Advancement of Science (AAAS)

Prize winner’s research reveals how complex neural circuits are correctly wired during brain development

Using single-cell RNA sequencing and genetic screening, the researchers identified key surface proteins that mediate ...