Powerful tool can map gene regulation at single-nucleotide resolution

Understanding how cells turn genes on and off is one of biology's most enduring mysteries. Now, a new technology developed by ...
eLife

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

This important study examines the potential role of ARHGAP36 transcriptional regulation by FOXC1 in controlling sonic hedgehog signaling in human neuroblastoma. While there are many solid findings ...
AlphaGalileo

A Major New Review On Single-Cell Multi-Omics Data Integration

Titled “A comparison of integration methods for single‐cell RNA sequencing data and ATAC sequencing data”, this paper ...
Frontiers

Integrating scRNA-seq and GWAS data reveals potentially critical endothelial cells in large artery atherosclerotic stroke

Introduction: Stroke is a devastating cerebrovascular disease with limited treatment options. Structural and functional abnormalities in the cerebral vasculature contribute significantly to the ...
eLife

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

Single-cell transcriptome sequencing results of rats intervened with specific mode electroacupuncture (an emerging method for opening the blood-brain barrier).
IEEE

scPEGEnhanced Graph Convolutional Sparse Subspace Clustering Method for scRNA-Seq Data

Abstract: The identification of cell types by clustering single-cell RNA sequencing (scRNA-seq) data is a fundamental step in the downstream analysis of single-cell data. However, great challenges ...
Frontiers

Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis

Background: Periodontitis, recognized as the second most prevalent oral disease globally, is strongly linked to systemic disorders like diabetes and cardiovascular diseases, highlighting the critical ...
BioSpace

Myeloid Therapeutics Unveils First-in-Human In Vivo mRNA CAR Data, Marking a Breakthrough in RNA-Based Immuno-Oncology at the 2025 ASCO Annual Meeting

– Initial translational results support proof-of-mechanism with immune reprogramming resulting in tumor penetration and pro-inflammatory alteration in the TME – CAMBRIDGE, Mass., May 30, 2025 ...