Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the ...

Human stem cells can differentiate into any human cell. But the process of dedifferentiation, essentially differentiation in reverse, is implicated in several diseases. Now researchers have uncovered ...

The function of an enzyme, critical to most forms of life, has been revealed. A research team, led by the John Innes Centre found that the enzyme DNA topoisomerase VI (topo VI) performs a critical ...

ESMs, a proteome-scale framework to classify loss-of-function missense variants into distinct mechanistic groups by combining two complementary state-of-the-art machine learning models. The strength ...

Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform ...

UPTON, NY—Scientists studying a COVID-19 coronavirus enzyme at temperatures ranging from frosty to human-body warm discovered subtle structural shifts that offer clues about how the enzyme works. The ...

The enzyme PI3K plays a critical role in cell migration. Scientists have long understood this function. But researchers have recently unveiled that a subunit of this enzyme also has the ability to ...

Cryo-EM reconstructions of the human ATR–ATRIP complex show how clinical small-molecule inhibitors like VE-822 and RP-3500 bind to and inhibit ATR activity. A research team led by Prof. Gang Cai and ...

A human enzyme converts chemicals produced by marine sponges and related synthetic derivatives into cell-killing compounds, shows a new study. A human enzyme converts chemicals produced by marine ...

Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...