The RAD52-DNA complex is a dynamic guardian of genomic stability. When this balance falters, cells may either self-destruct or, worse, turn cancerous.

Bowhead whales can live over 200 years thanks to a protein that helps their cells repair DNA damage efficiently.

A powerful new drug combination—niraparib added to standard prostate cancer therapy—has been shown to significantly delay ...

The combination of niraparib and abiraterone halves the spread of prostate cancer in men with BRCA gene mutations.

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy ...

Gerhardt Attard, M.D., Ph.D., from University College London, and colleagues conducted a double-blind trial that evaluated combining niraparib with AAP versus placebo and AAP in mCSPC with HRR gene ...

A major international study led by UCL researchers has found that combining two cancer drugs could substantially slow the progression of a severe and often deadly form of prostate cancer in men with ...

A targeted drug combination delays advanced prostate cancer in men with specific DNA repair gene mutations. A large international study led by researchers at UCL has found that a new combination of dr ...

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression. In ...

Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive tolerability profile, expected PK/PD activity, and promising clinical ...

One of the biggest challenges in cancer treatment is chemoresistance: tumors that initially respond well to chemotherapy become resistant over time ...