With a newly developed method that compares AI-generated protein sequences with naturally occurring ones, function- and ...

Proteomics is the large-scale study of proteins, particularly their structures and functions. It involves the systematic identification, quantification, and analysis of the entire protein complement ...

This story is part of a larger series on viroids and virusoids, small infectious RNAs. It is also the third installment in a series on hepatitis D virus, a virusoid-like pathogen that causes serious ...

A Jacobs School researcher is focused on learning more about how tight junctions form naturally — and how their breakdown can lead to disease.

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their study, published in Nature Communications, sheds new light on the interplay ...

Proteins are the "workhorses" in every living cell and constitute the chemical basis of life. These little machines are required to turn food into energy, to manage motion and brain activities and to ...

Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into ...

Viruses are invading pathogens that infect host cells and rapidly replicate throughout the body. They carry a small piece of genetic material such as DNA or RNA surrounded by a capsid that needs a ...

ESMs, a proteome-scale framework to classify loss-of-function missense variants into distinct mechanistic groups by combining two complementary state-of-the-art machine learning models. The strength ...