Cell transformation is associated with anchorage independent growth and morphological changes characterized by reduced adhesion and spreading. The molecular signals that control these events are ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Gardner’s team first focused their efforts on the challenging task of creating mouse strains that could recapitulate the complex transformation in a simplified model. “It took three years to make ...

The cells with electrophysiological activity obtained at the University of the Basque Country (UPV/EHU) are opening up new avenues for the study of neurodegenerative diseases and the development of ...

A three-drug regimen involving a PD-L1 inhibitor and two targeted agents was active and safe for treating the diffuse large B-cell lymphoma (DLBCL) variant of Richter transformation, the phase II ...

Membrane fusion and budding mediate fundamental biological processes like intracellular trafficking, exocytosis, and endocytosis. For many decades, fusion has been thought to open a nanometer-range ...

Around the same time, Mack Fulwyler, an engineer working at Los Alamos National Laboratory, needed to separate particles, so he drew on existing techniques to create droplets to separate cells from a ...

Two American biologists have won this year's Nobel Prize in Physiology or Medicine for discovering a crucial way genes are regulated. Two American biologists have won this year's Nobel Prize in ...

Scientists at UCSF identified a key cellular switch that plays a large role in pulmonary fibrosis, and found a way of blocking it to halt progression of the disease.