An international team of researchers report in the journal Nature Immunology that a mutation in the gene OTULIN causes ...

People who have an inflammatory bowel disease like ulcerative colitis often have problems caused by inflammation in other parts of their bodies. One of these is a skin condition called pyoderma ...

Pyoderma gangrenosum is a diagnosis of exclusion, and the misdiagnosis of pyoderma gangrenosum can result in substantial complications in patients who have other causes of severe cutaneous ulceration.

An international team of researchers has identified a genetic cause for a rare inflammatory skin condition.

A 2-point improvement in pain based on a numeric rating scale may indicate that patients are responding to treatment for pyoderma gangrenosum. To help determine whether a patient with pyoderma ...

Pyoderma gangrenosum was first described as an extraintestinal manifestation of inflammatory bowel disease (IBD) by Brunsting and colleagues in 1930. 1 They described painful enlarging necrotic ulcers ...

Leg ulcers form when skin on your leg breaks open. These breaks or sores let air and bacteria travel into your skin’s tissue. For most people, leg ulcers will heal on their own and won’t need medical ...

A 58-year-old woman presented to our emergency department with painful ulcers on the right side of her neck and on her left elbow. The ulcers, which had begun after minimal trauma, had increased in ...

A 59-year-old woman with systemic lupus erythematosus presented with a 1-month history of an enlarging, exquisitely painful ulcer on her left calf (Figure 1). She reported that it had occurred ...

Robert has to wrap his legs so tightly it feels "like an elastic band" ROBERT Lilley was diagnosed with a rare flesh-eating condition 12 years ago – and has lived in “unbearable pain” ever since. The ...