As one of a number of p53-regulated genes, Gadd45a (growth arrest and DNA damage inducible gene) has been shown to delay carcinogenesis and decrease mutation frequency. Gadd45a is known to regulate ...
The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...
The tumor suppressor p53 plays an important role in response to DNA damage, including DNA repair. One DNA repair pathway, nucleotide excision repair (NER), has been well-documented to be regulated by ...
Effects of TKI on patients with non-small cell lung cancer of different stages: A meta-analysis. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a ...
A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by ...
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2006 ASCO ...
A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...
In this Review, familial and sporadic neurological disorders reported to have an etiological link with DNA repair defects are discussed, with special emphasis placed on the molecular link between the ...
New University of Gloucestershire research aims to increase our understanding of the causes of human diseases, potentially leading to the design of better treatments in the future. The research, which ...
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