The former NFL Offensive Player of the Year accounted for 173 yards of total offense (106 rushing, 67 receiving) and two total touchdowns to carry the 49ers to their NFC West-leading sixth win of the season and make a bit of NFL history in the process.

But as always, the 49ers are significantly stronger whenever Christian McCaffrey is on the field. Against the Giants, he set multiple new records, with one achievement joining him to an exclusive club and placing him among a very select group of players to represent San Francisco.

NFL.com says teams are calling on Jauan Jennings, but with Aiyuk still ramping up and Shanahan signaling stability, a 49ers trade is unlikely.

The New York Giants didn't just lose to the San Francisco 49ers on Sunday afternoon. They lost the majority of the crowd at MetLife Stadium by the end of the 34-24 loss.

The San Francisco 49ers have reportedly shown interest in a big-time trade ahead of the Tuesday NFL trade deadline.

The 49ers improved to 6–3, beating the Giants 34–24 in Week 9 behind Christian McCaffrey’s record-breaking performance.

The New York Giants' defense has collapsed in recent weeks, and defensive end Kayvon Thibodeaux knows something needs to change.

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -143 money line favorites (risk $143 to win $100),

The San Francisco 49ers continue to find ways to win games, but at the end of every game, they seem to add another new name to the injury report. While some have been more serious than others, it appears as though edge rusher Mykel Williams' ACL injury could be a season-ending injury .